Subject(s)
Humans , Female , Child , Adiposis Dolorosa/metabolism , Rare Diseases/metabolism , Lipomatosis/metabolism , Pain/etiology , C-Reactive Protein , Adiposis Dolorosa/complications , Adiposis Dolorosa/diagnostic imaging , Rare Diseases/complications , Rare Diseases/diagnostic imaging , 1-Alkyl-2-acetylglycerophosphocholine Esterase/blood , Dyslipidemias/blood , Lipomatosis/diagnosis , Lipoproteins/blood , Cholesterol, HDL/bloodABSTRACT
Se plantea la importancia de los estudios de la composición corporal en distintas áreas del conocimiento y en diversos tipos de población. Se enuncian criterios básicos de uso común en el campo y se exponen algunos métodos de evaluación antropométrica, supuestos, limitaciones, y la conveniencia de su empleo en Salud Pública. Se enfatizan las dificultades de los métodos de laboratorio. La relación de los distintos componentes de la composición corporal con la excelencia atlética, y factores de riesgo asociados con la adiposidad y distribución del tejido es igualmente destacada. Se pone de manifiesto la necesidad de estandarización de los métodos de análisis y la elaboración de patrones locales
Subject(s)
Adiposis Dolorosa/diagnosis , Anthropometry/history , Health , Human Body , Sports/classificationABSTRACT
A case of a 43-year-old nonobese woman with adiposis dolorosa (Dercum's disease) is reported. Muscle glucose uptake and oxidation before and after ingestion of 75 g of glucose were similar to control group values, although a greater insulin release(16,578 vs 6,242 ñ 1,136 uU/3 h) occurred simultaneously. In vitro studies of abdominal normal and painful subcutaneous adipose tissue of the patient revealed lower responsiveness to norepinephrine and lack of response to the antilipolytic effect of insulin in the painful adipose tissue (0.98 vs 1.43 uM FFA/106 cells at 5.0 uM of norepinephrine). The disease was not correlated with the HLA system and there were no alterations in hormonal secretion at the pituitary, adrenal, gonadal, and thyroid levels. These findings indicate the presence of peripheral insulin resistance in this patient with adiposis dolorosa
Subject(s)
Adipose Tissue , Adiposis Dolorosa , Glucose/metabolism , Hormones , Insulin ResistanceABSTRACT
Los lipomas son tumores únicos o múltiples, desarrollados a partir del tejido adiposo. En sus formas múltiples constituyen las "lipomatosis", dando origen a cuadros clínicos raros y complejos. Se reconocen los siguientes cuadros: 1) Enfermedad de Dercum, afecta fundamentalmente a mujeres perimenopáusicas obesas, con disendocrinias, presentando tumores dolorosos en tronco y miembros; 2) Adenolipomatosis o Enfermedad de Launois-Bensaude, con afectación de hombres, disponiéndose en cuello, ingle y axilas, remedando adenopatías, 3) Lipomatosis mesosomática de Roch-Lery, con compromiso exclusivo de tronco y 4) Enfermedad de Touraine-Renault, disponiéndose en forma segmentaria o zoniforme
Subject(s)
Adiposis Dolorosa/pathology , Lipomatosis, Multiple Symmetrical/classification , Lipomatosis/classification , Adiposis Dolorosa/therapy , Alcoholism/complications , Diagnosis, Differential , Lipomatosis, Multiple Symmetrical/etiology , Lipomatosis/pathology , Lipoma/pathology , Skin NeoplasmsABSTRACT
The patient was a sixty-year-old obese woman with the long history of hypertension, amenorrhea and occasional psychic disturbances. She had eigbt, thumb to adult-fist sized, slightly movable, relatively soft, and painful subcutaneous nodules with tenderness and paresthcsia, of which overlying skin appeared to be normal except senile changes, on the abdomen and both upper extremities for 10 years. There was no evidence of inheritance in her family. Laboratory data revealed no abnormalities in lipid metabolism or in a variety of endocrinological functions. Microscopically, an excised mass from the forearm showed thin connective tissue capsule encircling numerous lobules cornposed entirely of the mature fat. cells vith minimal focal capillary proliferatios.
Subject(s)
Female , Humans , Abdomen , Adiposis Dolorosa , Amenorrhea , Capillaries , Connective Tissue , Forearm , Hypertension , Lipid Metabolism , Skin , Thumb , Upper Extremity , WillsABSTRACT
Cem mulheres com queixas de dor no joelho foram prospectivamente estudadas. Entre elas foram encontrados 12 casos de adiposidade dolorosa justa-articular dos joelhos. Esta patologia é identificada pela presença de adiposidade dolorosa na face medial de ambos os joelhos e deve ser entendida como uma entidade perfeitamente individualizada. Nossas pacientes apresentavam as seguintes características básicas: obesidade, pé plano, joelho valgo e história familiar de adiposidade dolorosa. De acordo com os nossos dados e com os da literatura, a adiposidade dolorosa justa-articular pode, talvez, ser incluída no espectro da doença de Dercum